Neutrophil activation and neutrophil derived neutrophil extracellular trap formation in patients with coronary artery ectasia
نویسندگان
چکیده
منابع مشابه
Mechanical ventilation induces neutrophil extracellular trap formation.
BACKGROUND Mechanical ventilation can injure the lung and induce a proinflammatory state; such ventilator-induced lung injury (VILI) is associated with neutrophil influx. Neutrophils release DNA and granular proteins as cytotoxic neutrophil extracellular traps (NETs). The authors hypothesized that NETs were produced in a VILI model and may contribute to injury. METHODS In a two-hit lipopolysa...
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BACKGROUND During systemic inflammation, leucocytes are activated and extravasate into damaged tissue. Activation and recruitment are influenced by different mechanisms, including the interaction of leucocytes with platelets and neutrophil extracellular traps (NET) formation. Here, we investigated the molecular mechanism by which hydroxyethyl starch (HES 130/0.4) dampens systemic inflammation i...
متن کاملInfluences of Chloride and Hypochlorite on Neutrophil Extracellular Trap Formation
BACKGROUND The release by neutrophils of DNA-based extracellular traps (NETs) is a recently recognized innate immune phenomenon that contributes significantly to control of bacterial pathogens at tissue foci of infection. NETs have also been implicated in the pathogenesis of non-infectious diseases such as small vessel vasculitis, lupus and cystic fibrosis lung disease. Reactive oxygen species ...
متن کاملP-selectin promotes neutrophil extracellular trap formation in mice.
Neutrophil extracellular traps (NETs) can be released in the vasculature. In addition to trapping microbes, they promote inflammatory and thrombotic diseases. Considering that P-selectin induces prothrombotic and proinflammatory signaling, we studied the role of this selectin in NET formation. NET formation (NETosis) was induced by thrombin-activated platelets rosetting with neutrophils and was...
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ژورنال
عنوان ژورنال: BMC Cardiovascular Disorders
سال: 2020
ISSN: 1471-2261
DOI: 10.1186/s12872-020-01398-0